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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $176.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $545.00 |
About This Item
Empirical Formula (Hill Notation):
C23H21BrN2O2S
Molecular Weight:
469.39
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +260 to +300°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Potent and selective protein arginine methyltransferase PRMT6 inhibitor.
SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 77 nM by cell-free assays; IC50 = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description recombinant, expressed in E. coli, ≥70% (SDS-PAGE) | description affinity isolated antibody |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥70% (SDS-PAGE) | assay - |
| form powder | form powder | form aqueous solution | form buffered aqueous solution |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility - | solubility - |
| color white to beige | color white to beige | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
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