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SML2760

SGC6870

≥98% (HPLC)

Synonym(s):

(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$176.00
25 mg

Available to ship TODAYfromMILWAUKEE

$545.00

About This Item

Empirical Formula (Hill Notation):
C23H21BrN2O2S
Molecular Weight:
469.39
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder

$176.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +260 to +300°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Potent and selective protein arginine methyltransferase PRMT6 inhibitor.
SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 77 nM by cell-free assays; IC50 = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.

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This Item
SML2761SRP0389SAB2106502
description

≥98% (HPLC)

description

≥98% (HPLC)

description

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

description

affinity isolated antibody

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥70% (SDS-PAGE)

assay

-

form

powder

form

powder

form

aqueous solution

form

buffered aqueous solution

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3



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