The solubility of this material is tested in DMSO. The solubility in water has not been determined. However, external sources indicate that Pyridostatin hydrochloride is soluble in water at 1 mM. Solutions may be stored up to 1 month at -20°C (store solutions under nitrogen). The HCl content varies from lot to lot and may range from 4.5 to 5.5 mol/mol. The water content may also range from 0.0 - 7.0 mol/mol. This information is reported in the Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/sml2690#product-documentation
SML2690
Pyridostatin hydrochloride
≥98% (HPLC), powder, G-quadruplex DNA stabilizing agent
Synonym(s):
4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide hydrochloride, 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide hydrochloride, RR 82 HCl, RR-82 HCl, RR82 HCl
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $126.00 |
25 mg | Check Cart for Availability | $506.00 |
About This Item
Empirical Formula (Hill Notation):
C31H32N8O5 · xHCl
Molecular Weight:
596.64 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Product Name
Pyridostatin hydrochloride, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NCCOc1cc(nc(c1)C(=O)Nc4nc5c(c(c4)OCCN)cccc5)C(=O)Nc2nc3c(c(c2)OCCN)cccc3
InChI key
VGHSATQVJCTKEF-UHFFFAOYSA-N
Application
Pyridostatin hydrochloride has been used as a G-quadruplex (G4)-stabilizing ligand to check the effect of G4s on fork progression. It has also been used as a G4-stabilizing ligand to study the effect of G4 on apurinic/apyrimidinic endonuclease 1 (APE1) mediated Kirsten rat sarcoma virus (KRAS) expression in pancreatic ductal adenocarcinoma (PDAC) cell lines.
Biochem/physiol Actions
Pyridostatin is a highly selective G-quadruplex (G4) interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage. Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G4, inducing DNA damage and cell-cycle arrest.
Stabilizer of G-quadruplexes (G4).
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | description United States Pharmacopeia (USP) Reference Standard | description PESTANAL®, analytical standard |
| form powder | form lyophilized | form - | form - |
| assay ≥98% (HPLC) | assay ≥98% (SDS-PAGE), ≥98% (HPLC) | assay - | assay - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. - | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| color white to beige | color white to off-white | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Hi, I need to make up a known concentration solution of this compound, but you only supply a free base molecular weight. Can you provide me with a full molecular weight for lot #0000374186? Also, what's the storage and water solubility? Thanks in advance
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