Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML2636

Sigma-Aldrich

Sb4

≥98% (HPLC)

Synonym(s):

2-[[(4-Bromophenyl)methyl]thio]benzoxazole, BMP signaling agonist Sb4

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$78.45
25 MG
$193.20

$78.45

List Price$85.00Save 8%
Web-Only Promotion

Available to ship onApril 15, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$78.45
25 MG
$193.20

About This Item

Empirical Formula (Hill Notation):
C14H10BrNOS
CAS Number:
100874-08-6
Molecular Weight:
320.20
MDL number:
MFCD01603921
UNSPSC Code:
12352200
NACRES:
NA.77

$78.45

List Price$85.00Save 8%
Web-Only Promotion

Available to ship onApril 15, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1

InChI

1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2

InChI key

JDVOIBFEFVKUPL-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML1530SML2218SML0711
Sb4 ≥98% (HPLC)

SML2636

Sb4

SB-334867 ≥98% (HPLC)

SML1530

SB-334867

SNS-032 ≥98% (HPLC)

SML2218

SNS-032

RS504393 ≥98% (HPLC)

SML0711

RS504393

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL

solubility

DMSO: 1 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293)
Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Shayna T J Bradford et al.
The Journal of biological chemistry, 294(9), 3125-3136 (2019-01-04)
Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to be protective by promoting renal repair and regeneration. Clinical use of recombinant BMPs

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service