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SML2470

Sigma-Aldrich

GYY4137 sodium, dichloromethane-free

≥98% (HPLC)

Synonym(s):

(4-Methoxyphenyl)-4-morpholinyl-phosphinodithioic acid, sodium salt, GYY4137 Na salt, GYY4137 sodium salt, Na-GYY4137, Sodium 4-methoxyphenyl(morpholino)phosphinodithioate, Sodium GYY4137

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5 MG
$119.70
25 MG
$453.01

$119.70

List Price$126.00

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5 MG
$119.70
25 MG
$453.01

About This Item

Empirical Formula (Hill Notation):
C11H15NNaO2PS2
CAS Number:
1975149-21-3
Molecular Weight:
311.34
UNSPSC Code:
12352200
NACRES:
NA.77

$119.70

List Price$126.00

In StockDetails

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

[S-]P(C1=CC=C(C=C1)OC)(N2CCOCC2)=S.[Na+]

InChI

1S/C11H16NO2PS2.Na/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;/h2-5H,6-9H2,1H3,(H,16,17);/q;+1/p-1

Inchi Key

ZFQXKWOUNSKHAG-UHFFFAOYSA-M

Biochem/physiol Actions

GYY4137 sodium (Na-GYY4137) is a dichloromethane-free, water-soluble sodium salt form of the slow-releasing hydrogen sulfide (H2S) donor GYY4137. Na-GYY4137 is devoid of potential off-target effects associated with the use of dichloromethane-complexed GYY4137 morpholine salt form. Morpholine is biologically active and toxic (LD50 range of 300-500 mg/kg in rodents), while dichloromethane is carcinogenic and can metabolize in vivo to carbon monoxide, causing unintended CO-dependent effects.
Water soluble, non-toxic alternative to the dichloromethane-containing morpholine salt form of the hydrogen sulfide (H2S) donor GYY4137.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Eva Latorre et al.
Aging, 10(7), 1666-1681 (2018-07-22)
Cellular senescence is a key driver of ageing, influenced by age-related changes to the regulation of alternative splicing. Hydrogen sulfide (H2S) has similarly been described to influence senescence, but the pathways by which it accomplishes this are unclear.We assessed the
Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137
Lehto SG, Weyer AD, Youngblood BD, Zhang M, Yin R, Wang W, Teffera Y, Cooke M, Stucky CL, et al
MedChemComm, 6, 1649-1655 (2015)

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