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SML2449

THIQ

≥98% (HPLC)

Synonym(s):

(3R)-N-[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide, (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclo-hexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

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5 mg
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$176.00
$149.60
25 mg
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$569.00

About This Item

Empirical Formula (Hill Notation):
C33H41ClN6O2
CAS Number:
Molecular Weight:
589.17
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$149.60

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N1CCC(CN2N=CN=C2)(C3CCCCC3)CC1)[C@@H](CC4=CC=C(Cl)C=C4)NC([C@@H]5NCC6=CC=CC=C6C5)=O

InChI

1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1

InChI key

HLCHESOMJVGDSJ-LOYHVIPDSA-N

Biochem/physiol Actions

THIQ is a selective tetrahydroisoquinoline melanocortin-4 receptor (MC4R) agonist. It exhibited an IC50 vaue of 1.2 nM in MC4R human receptors expressed in CHO cells compared values of 2067, 761 and 326 nM for MC1R, MC3R, and MC5R receptors, respectively.
Tetrahydroisoquinoline melanocortin-4 receptor (MC4R) agonist

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description

≥98% (HPLC)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

assay

≥98% (HPLC)

assay

-

form

powder

form

buffered aqueous glycerol solution

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to beige

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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