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SML2089

NCT-501

≥98% (HPLC)

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Synonym(s):

NCT-501, 8-((4-(Cyclopropanecarbonyl)piperazin-1-yl)-methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione, 8-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromMILWAUKEE

$145.00

About This Item

Empirical Formula (Hill Notation):
C21H32N6O3
CAS Number:
Molecular Weight:
416.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$145.00

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CN1C(N(C)C2=C(N(CCC(C)C)C(CN3CCN(C(C4CC4)=O)CC3)=N2)C1=O)=O

InChI key

FSXIBBYWVGWQJL-UHFFFAOYSA-N

Biochem/physiol Actions

NCT-501 is a potent and selective inhibitor of Aldehyde dehydrogenase ALDH1A1, a dehydrogenase that has been found to be elevated in certain cancers and in cancer stem cells. NCT-501 had an IC50 value of 40 nM and was found to be 1000-fold selective for ALDH1A1 over other ALDH enzymes and other dehydrogenases. NCT-501 treatment of head and neck squamous-cell carcinoma (HNSCC) explants in combination with cisplatin resulted in a significant decrease in proliferating cells.
Potent and selective inhibitor of Aldehyde dehydrogenase ALDH1A1

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This Item
SML2607T1633D0633
description

≥98% (HPLC)

description

≥98% (HPLC)

description

anhydrous, ≥99%, powder

description

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99%

assay

-

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

0.1 M NaOH: soluble, dilute HCl: soluble, ammonium hydroxide: soluble, NH4OH: 50 mg/ml, clear, colorless, H2O: slightly soluble 8.3 mg/ml, 0.1 M HCl: soluble, ethanol: moderately soluble, alcohol: 12.5 mg/ml, diethyl ether: slightly soluble, dilute nitric acid: soluble, aqueous base: soluble, chloroform: soluble 9.1 mg/ml

solubility

-

color

white to beige

color

white to beige

color

white

color

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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