SML1971

LLY-284

≥98% (HPLC)

• Synonym(s): (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol, (S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine, LLY 284, LLY284
• Empirical Formula (Hill Notation): C₁₇H₁₈N₄O₄
• CAS Number: 2226515-75-7
• Molecular Weight: 342.35
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O

Description

Biochem/physiol Actions

LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.

LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable