SML1712
SBC-115076
≥98% (HPLC)
Synonym(s):
1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $141.00 |
About This Item
Empirical Formula (Hill Notation):
C31H33N3O5
CAS Number:
Molecular Weight:
527.61
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
$141.00
Check Cart for Availability
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5
Biochem/physiol Actions
SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9).
SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9). PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. SBC-115076 was shown to inihbit PCSK9, blocking LDLR degradation in HEK293T cells expressing PCSK9 and to increase the uptake of LDL by liver cells in vitro. SBC-115076 lowered cholesterol levels in mice fed a high fat diet.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description culture supernatant, clone 9B3.1, from mouse | description affinity isolated antibody, buffered aqueous solution | description for serum, plasma and cell culture supernatants |
| form powder | form - | form buffered aqueous solution | form - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 20 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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