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SML1638

VX-745

≥98% (HPLC)

Synonym(s):

5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$119.00
$123.00
25 mg

Available to ship TODAYfromMILWAUKEE

$480.00

About This Item

Empirical Formula (Hill Notation):
C19H9Cl2F2N3OS
CAS Number:
Molecular Weight:
436.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$123.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1

InChI

1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H

InChI key

VEPKQEUBKLEPRA-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Biochem/physiol Actions

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα.
VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.

Other Notes

VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.

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SML2493SAB5600059SAB4500491
description

≥98% (HPLC)

description

≥98% (HPLC)

description

recombinant, expressed in HEK 293 cells, clone RM245, purified immunoglobulin

description

affinity isolated antibody

form

powder

form

powder

form

buffered aqueous glycerol solution

form

buffered aqueous solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3



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