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SML1492

UMI-77

≥98% (HPLC)

Synonym(s):

2-[[4-[[(4-Bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid

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Size/SKUAvailabilityPrice
5 mg
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$123.00
25 mg
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$398.00

About This Item

Empirical Formula (Hill Notation):
C18H14BrNO5S2
CAS Number:
Molecular Weight:
468.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$123.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

OC1=C(SCC(O)=O)C=C(NS(C2=CC=C(Br)C=C2)(=O)=O)C3=CC=CC=C31

InChI

1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)

InChI key

WUGANDSUVKXMEC-UHFFFAOYSA-N

Biochem/physiol Actions

UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1, a member of the Bcl-2 family that inhibits apoptosis. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. It inhibited cell growth and induced apoptosis in pancreatic cancer cells.
UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1.

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This Item
SML2090
description

≥98% (HPLC)

description

≥98% ruthenium (Ru) basis (elemental analysis)

assay

≥98% (HPLC)

assay

≥98% ruthenium (Ru) basis (elemental analysis)

form

powder

form

powder

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

color

white to beige

color

faint red to dark brown


Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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