SML1238

Ertapenem sodium

≥90% (HPLC), powder, carbopenem antibiotic

• Synonym(s): (4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium, ZD-443 sodium
• Empirical Formula (Hill Notation): C₂₂H₂₄N₃O₇S · Na
• CAS Number: 153773-82-1
• Molecular Weight: 497.50
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• product name: Ertapenem sodium, ≥90% (HPLC)
• Quality Level: 100
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated; protect from light
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• shipped in: wet ice
• storage temp.: −70°C
• InChI: 1S/C22H25N3O7S.Na/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30;/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32);/q;+1/p-1/t9-,10-,13+,14+,15-,16-;/m1./s1
• InChI key: ZXNAQFZBWUNWJM-HRXMHBOMSA-M

Description

Application

Ertapenem sodium has been used as a carbapenem in the NitroSpeed-Carba NP test in minimum inhibitory concentration (MIC) testing for differentiation of carbapenemases in Enterobacterales and Pseudomonas aeruginosa. It has also been used as an antibiotic to study its effects on the survival of septic mice.

Biochem/physiol Actions

Ertapenem is a broad spectrum carbopenem antibiotic. Ertapenem is active against both gram-positive and gram-negative bacteria. Ertapenem shows an extended duration of action in vivo due to its reversible binding to serum protein.

Ertapenem sodium exhibits its activity against several aerobic and anaerobic microorganisms and is more resistant to β-lactamase enzymes. It has been studied in the treatment of several infectious diseases.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable