Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML1104

Sigma-Aldrich

NQTrp

≥98% (HPLC)

Synonym(s):

1,4-Naphthoquinon-2-yl-l-tryptophan, N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$103.00
25 MG
$416.00

$103.00

In StockDetails

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$103.00
25 MG
$416.00

About This Item

Empirical Formula (Hill Notation):
C21H16N2O4
CAS Number:
185351-19-3
Molecular Weight:
360.36
MDL number:
MFCD21496345
UNSPSC Code:
12352200
PubChem Substance ID:
329825479
NACRES:
NA.77

$103.00

In StockDetails

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

, orange to dark orange-red

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=CC(C4=C1C=CC=C4)=O

InChI

1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1

InChI key

DZZUYZXINNHEGM-SFHVURJKSA-N

Biochem/physiol Actions

NQTrp is a potent inhibitor of amyloid aggregation (AD).
NQTrp is a potent inhibitor of amyloid aggregation (AD). NQTrp completely inhibits Ab oligomerization and fibrillization, and the cytotoxic effect of Ab oligomers in cultured neuronal cell line.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
074M4621V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Moran Frenkel-Pinter et al.
Journal of Alzheimer's disease : JAD, 51(1), 165-178 (2016-02-03)
Tauopathies, such as Alzheimer's disease (AD), are a group of disorders characterized neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed by misfolding of the microtubule-associated protein tau. Since protein self-assembly appears to be an initial key step in
Olivia Berthoumieu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(36), 12657-12666 (2015-07-17)
Inhibition of the aggregation of the monomeric peptide β-amyloid (Aβ) into oligomers is a widely studied therapeutic approach in Alzheimer's disease (AD). Many small molecules have been reported to work in this way, including 1,4-naphthoquinon-2-yl-L-tryptophan (NQ-Trp). NQ-Trp has been reported

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service