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Roflumilast

Name: Roflumilast
Brand: SIGMA
Price: 81.1 USD
Availability: InStock

≥98% (HPLC), powder, phosphodiesterase 4 PDE4 inhibitor

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Synonym(s):

3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide

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Size/SKU	Availability	Price
10 mg	Available to ship TODAYfromMILWAUKEE	$81.10
50 mg	Available to ship TODAYfromMILWAUKEE	$327.00

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₄Cl₂F₂N₂O₃

CAS Number:

162401-32-3

Molecular Weight:

403.21

UNSPSC Code:

41106305

PubChem Substance ID:

329825476

NACRES:

NA.77

MDL number:

MFCD00938270

Assay:

≥98% (HPLC)

Form:

powder

$81.10

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Properties

Product Name

Roflumilast, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O

InChI

1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChI key

MNDBXUUTURYVHR-UHFFFAOYSA-N

Gene Information

human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Description

Application

Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice. It is also used to investigate its therapeutic potential to ameliorate primary blast-induced deficits in long-term potentiation (LTP).

Biochem/physiol Actions

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item	1605012	SML1602	SML0585
Sigma-Aldrich SML1099 Roflumilast	USP 1605012 Roflumilast	Sigma-Aldrich SML1602 RQ-00203078	Sigma-Aldrich SML0585 Piclamilast
description ≥98% (HPLC)	description United States Pharmacopeia (USP) Reference Standard	description ≥98% (HPLC)	description ≥98% (HPLC)
form powder	form -	form powder	form powder
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility -	solubility DMSO: 25 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
color white to beige	color -	color white to beige	color white to beige

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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