SML0885

bpV(pic)

≥95% V basis

• Synonym(s): Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K₂ [VO(O₂)2C₆H₄NO₂] · 2 H₂O
• Empirical Formula (Hill Notation): K₂VOO₂O₂C₆H₄NO₂ · 2H₂O
• CAS Number: 148556-27-8
• Molecular Weight: 367.27
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% V basis
• Form: powder
• Storage condition: protect from light

Properties

• Quality Segment: 100
• assay: ≥95% V basis
• form: powder
• storage condition: protect from light
• color: faintly yellow to dark yellow
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C

Description

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Biochem/physiol Actions

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.

Other Notes

Light Sensitive

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable