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SML0863

Sigma-Aldrich

A-1070722

≥98% (HPLC)

Synonym(s):

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

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About This Item

Empirical Formula (Hill Notation):
C17H13F3N4O2
CAS Number:
1384424-80-9
Molecular Weight:
362.31
UNSPSC Code:
12352200
NACRES:
NA.77

$88.20

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1nc(ccc1)NC(=O)Nc2c3c(ncc2)cc(cc3)OC

InChI

1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)

InChI key

VQPBIJGXSXEOCU-UHFFFAOYSA-N

Biochem/physiol Actions

A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A-1070722 showed > 50-fold selectivity for GSK-3 over a panel of other kinases tested, including CDK family members. A-1070722 decreased phosphorylation of microtubule-associated protein Tau and protected rat primary cortical neurons against β amyloid and glutamate challenge.
A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms.

Features and Benefits

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000241335
0000175430
103M4607V

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Articles

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

PKB/Akt

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