SML0773

GSK-650394

≥98% (HPLC)

• Synonym(s): 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid, GSK 650394, GSK650394
• Empirical Formula (Hill Notation): C₂₅H₂₂N₂O₂
• CAS Number: 890842-28-1
• Molecular Weight: 382.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: [nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3
• InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
• InChI key: WVSBGSNVCDAMCF-UHFFFAOYSA-N

Description

Application

GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.

Biochem/physiol Actions

GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.

GSK-650394 is a potent, selective SGK1 antagonist.

GSK-650394 has an IC₅₀ value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2.PMID 23487453 It has an ability to stop viral replication at concentrations that are nontoxic to cells.PMID 23487453

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable