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SML0743

EUK-134

≥95% (HPLC), amyloid fibril formation blocker, powder

Synonym(s):

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese, 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex, Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2′,O1,O1′]-manganese, EUK 134

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$85.70
50 mg

Available to ship TODAYfromMILWAUKEE

$335.00
$284.75

About This Item

Empirical Formula (Hill Notation):
C18H18ClMnN2O4
CAS Number:
81065-76-1
Molecular Weight:
416.74
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated

$85.70

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Product Name

EUK-134, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

, faint to very dark brown

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

[Mn+2]Cl.N(=Cc2c(c(ccc2)OC)[O-])CCN=Cc1c(c(ccc1)OC)[O-]

InChI

1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3

InChI key

YUZJJFWCXJDFOQ-UHFFFAOYSA-K

Application

EUK-134 has been used as an antioxidant.
EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs).

Biochem/physiol Actions

EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities and inhibits amyloid fibril formation.
EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Other Notes

air sensitive

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This Item
SML0742SML153376854
EUK-134 ≥95% (HPLC)

Sigma-Aldrich

SML0743

EUK-134

EUK-8 ≥95% (HPLC)

Sigma-Aldrich

SML0742

EUK-8

(±)-Marinopyrrole A ≥95% (HPLC)

Sigma-Aldrich

SML1533

(±)-Marinopyrrole A

(S)-(−)-5,5′-Dichloro-2,2′-bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl ≥97.0% (H-NMR)

Sigma-Aldrich

76854

(S)-(−)-5,5′-Dichloro-2,2′-bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl

description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥97.0% (H-NMR)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97.0% (H-NMR)

form

powder

form

powder

form

powder

form

crystals

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

H2O: 1 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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