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SML0698

CID 11210285 hydrochloride

≥98% (HPLC)

Synonym(s):

2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine hydrochloride, AMBMP, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride, Wnt Agonist

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5 mg

Available to ship TODAYfromMILWAUKEE

$130.00
$135.00
25 mg

Available to ship TODAYfromMILWAUKEE

$362.00

About This Item

Empirical Formula (Hill Notation):
C19H18N4O3 · HCl
CAS Number:
853220-52-7
Molecular Weight:
386.83
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(Cc3cc4c(cc3)OCO4)c1nc(nc(c1)c2cc(ccc2)OC)N

InChI

1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChI key

FABQUVYDAXWUQP-UHFFFAOYSA-N

Application

CID 11210285 hydrochloride has been used as a Wnt agonist.

Biochem/physiol Actions

CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β.
CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β. CID 11210285is a Wnt agonist.

Other Notes

Light sensitve and air sensitive.

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This Item
681664681665
CID 11210285 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0698

CID 11210285 hydrochloride

Wnt Agonist I in DMSO The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681664

Wnt Agonist I in DMSO

Wnt Agonist The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681665

Wnt Agonist

description

≥98% (HPLC)

description

The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

description

The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

form

powder

form

liquid

form

solid (sticky)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

storage condition

desiccated

storage condition

OK to freeze, desiccated (hygroscopic), avoid repeated freeze/thaw cycles, protect from light

storage condition

OK to freeze, protect from light

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

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Questions

  1. What other vehicles can be used for the administration of the agonist in a mouse model? It can be administered locally (bone tissue) or only systemically?

    1 answer

    1. This product has not been tested for in vivo or in vitro applications. The method of administration will need to be validated by the end user. It may be helpful to view peer-reviewed articles. Please see the two publications below :

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662016/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565963/

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