SML0627

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

• Synonym(s): 1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1
• Empirical Formula (Hill Notation): C₂₂H₂₂N₂O₃
• CAS Number: 332382-54-4
• Molecular Weight: 362.42
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Product Name: ML-SA1, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C
• InChI: 1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
• InChI key: KDDHBJICVBONAX-UHFFFAOYSA-N

Description

Application

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca²⁺]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable