SML0326

GTS-21

≥97% (HPLC), α7 Nicotinic Acetylcholine Receptor Agonist, powder

• Synonym(s): 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride, DMBX-anabaseine, DMXB, DMXB-A, GTS21
• Empirical Formula (Hill Notation): C₁₉H₂₀N₂O₂ · 2HCl
• CAS Number: 156223-05-1
• Molecular Weight: 381.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825331
• NACRES: NA.77
• MDL number: MFCD00941364
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Product Name: GTS-21, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: H₂O: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.COc1ccc(\C=C2/CCCN=C2c3cccnc3)c(OC)c1
• InChI: 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
• InChI key: BXKYFUGAAFLYJL-BXGYHSFXSA-N

Description

Application

GTS-21 has been used:

• as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages
• to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)
• to test its effect on microvascular inflammation in endotoxemia induced by LPS

Biochem/physiol Actions

GTS-21 is a selective agonist at α-7 nicotinic receptors with anti-inflammatory and cognition enhancing activities. GTS-21 has also been investigated for the treatment of schizophrenia.

GTS-21 is a selective agonist at α-7 nicotinic receptors.

GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable