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SML0294

ABL127

≥98% (HPLC)

Synonym(s):

(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester, (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate, CID24856225

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship onSeptember 21, 2026fromMILWAUKEE

$696.00
$721.00

About This Item

Empirical Formula (Hill Notation):
C17H20N2O5
CAS Number:
Molecular Weight:
332.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
film

$721.00

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Estimated to ship onSeptember 21, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

film

color

colorless

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O

InChI

1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1

InChI key

ZRHWCAFAIHTQKD-KRWDZBQOSA-N

Biochem/physiol Actions

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1).
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

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This Item
SML190297023N8878
description

≥98% (HPLC)

description

≥98% (HPLC)

description

analytical standard

description

≥98%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99.0% (T), ≥97.0% (TLC)

assay

≥98%

form

film

form

powder

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

chloroform: 50 mg/mL

color

colorless

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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