SML0218

Bropirimine

≥98% (HPLC)

• Synonym(s): 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone, NSC 149027, PNU 54461, U 54461, U 54461S
• Empirical Formula (Hill Notation): C₁₀H₈BrN₃O
• CAS Number: 56741-95-8
• Molecular Weight: 266.09
• NACRES: NA.77
• PubChem Substance ID: 329825238
• UNSPSC Code: 41116107
• MDL number: MFCD01689128
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: ≥5 mg/mL (warm DMSO)
• storage temp.: room temp
• SMILES string: NC1=NC(=O)C(Br)=C(N1)c2ccccc2
• InChI: 1S/C10H8BrN3O/c11-7-8(6-4-2-1-3-5-6)13-10(12)14-9(7)15/h1-5H,(H3,12,13,14,15)
• InChI key: CIUUIPMOFZIWIZ-UHFFFAOYSA-N

Description

Application

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Biochem/physiol Actions

Bropirimine is an immunostimulant, anti-tumor agent

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Codes: H361
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable