SML0085

A-967079

≥98% (HPLC), Selective Transient Receptor Potential Anykrin 1 (TRPA1) antagonist, powder

• Synonym(s): (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime
• Empirical Formula (Hill Notation): C₁₂H₁₄FNO
• CAS Number: 1170613-55-4
• Molecular Weight: 207.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825146
• NACRES: NA.25
• MDL number: MFCD20488058
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: A-967079, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥12 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: CCC(=N/O)\C(C)=C\c1ccc(F)cc1
• InChI: 1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
• InChI key: HKROEBDHHKMNBZ-CHBKHGQFSA-N

Description

General description

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Application

A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Biochem/physiol Actions

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC₅₀′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

TRPA1 receptor antagonist

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable