SAB4300040

Anti-phospho-CREB1 (pSer¹³³) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CREB antibody produced in rabbit, Anti-MGC9284 antibody produced in rabbit, Anti-cAMP responsive element binding protein 1 antibody produced in rabbit
• MDL number: MFCD01092316
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~43 kDa
• species reactivity: mouse, human, rat
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (R-P-SP-Y-R)
• NCBI accession no.: NP_004370.1
• UniProt accession no.: P16220
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer133)
• Gene Information: human ... CREB1(1385)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R), according to the protein CREB1.

Features and Benefits

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Target description

CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable