SAB3500315

Anti-TRIAD3A antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: predicted mol wt 95 kDa
• species reactivity: mouse, human
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: AAP47174
• UniProt accession no.: Q9NWF9
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RNF216(54476)

Description

General description

Ring finger protein 216 (RNF216) is an E3 ubiquitin ligase. The gene encoding this protein is localized on human chromosome 7p22.3.

Immunogen

TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.

Biochem/physiol Actions

Ring finger protein 216 (RNF216) associates with toll-like receptors and aids in their degradation. It also aids in the degradation of receptor interacting protein-1 (RIP-1) kinase and negatively modulates tumor necrosis α receptor signaling. The protein acts as an inhibitor of autophagy in macrophages. Mutations in the RNF216 gene have been associated with Gordon Holmes syndrome.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500315.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable