S8753

Strychnine hydrochloride

• Empirical Formula (Hill Notation): C₂₁H₂₂N₂O₂ · HCl
• CAS Number: 1421-86-9
• Molecular Weight: 370.87
• EC Number: 215-826-9
• MDL number: MFCD00058174
• UNSPSC Code: 12352210
• PubChem Substance ID: 24899812
• NACRES: NA.32

Properties

• SMILES string: Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
• InChI: 1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
• InChI key: VLXYTKMPCOQKEM-ZEYGOCRCSA-N

Description

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions.[1][2] It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.[3]

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Strychnine is a potent convulsant,[4] which is extracted from Strychnos nux vomica seeds.[5] At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.[6]

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H300 + H330,H410
• pcodes: P260 - P264 - P271 - P273 - P284 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges