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S1885

Sigma-Aldrich

Suberic acid bis(N-hydroxysuccinimide ester)

≥95%, powder

Synonym(s):

Disuccinimidyl suberate, Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O8
CAS Number:
68528-80-3
Molecular Weight:
368.34
MDL number:
MFCD00049059
UNSPSC Code:
12352100
PubChem Substance ID:
24899500
NACRES:
NA.21

assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

solubility

chloroform: 50 mg/mL
DMF: soluble
aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.)

storage temp.

2-8°C

SMILES string

O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

InChI key

ZWIBGKZDAWNIFC-UHFFFAOYSA-N

General description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

Application

Suberic acid bis(N-hydroxysuccinimide ester) has been:
  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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