RAB0447

Phospho-Stat3 (pTyr⁷⁰⁵) and pan-Stat3 ELISA Kit

for detection of phospho-stat3 (pTyr⁷⁰⁵) and pan-stat3 in human, mouse or rat cell and tissue lysates

• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: human ... STAT3(6774) ; mouse ... STAT3(20848) ; rat ... STAT3(25125)
• Species reactivity: human, mouse, rat
• Storage temp.: −20°C
• Shipped in: wet ice

Properties

• species reactivity: human, mouse, rat
• technique(s): ELISA: suitable, capture ELISA: suitable
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... STAT3(6774) ; mouse ... STAT3(20848) ; rat ... STAT3(25125)

Description

General description

Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that belongs to the family of STAT proteins. The protein contains an Src homology 2 (SH2) domain for protein-protein interactions.[1] STAT3 is activated by phosphorylation on tyrosine 705 by c-Jun N-terminal kinases (JNKs), cytokine receptor-associated kinases, nonreceptor tyrosine kinases, and growth factor receptor tyrosine kinases, in response to growth factors and cytokines.[1][2] Phosphorylation of STAT3 is important for dimer formation and gene expression.[1][2] STAT3 mediates the expression of a variety of genes that are involved in cell proliferation and differentiation. It also aids in pro-cancer immunity. The Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA (enzyme-linked immunosorbent assay) is a very rapid, convenient, and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

The Phospho-Stat3 (pTyr⁷⁰⁵) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

Immunogen

Stat3 (pTyr⁷⁰⁵) synthetic phosphopeptide, Recombinant Human Stat3

Application

Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit has been used in enzyme-linked immunosorbent assay (ELISA) for quantitative measurement of phosphorylated signal transducer and activator of transcription3 (p-STAT3) in liver tissues.[3][4]

Safety Information

• pictograms: GHS05
• signalword: Warning
• hcodes: H290
• pcodes: P234 - P390
• Hazard Classifications: Met. Corr. 1
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Storage Class: 12 - Non Combustible Liquids