R137

Ro 31-0432

solid

• Synonym(s): 3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride, 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride, Bisindoylmaleimide XI
• Empirical Formula (Hill Notation): C₂₈H₂₈N₄O₂ · HCl
• CAS Number: 145333-02-4
• Molecular Weight: 489.01
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824001
• NACRES: NA.77
• Assay: ≥98% (TLC)
• Form: solid
• Storage condition: protect from light

Properties

• biological source: synthetic (organic)
• assay: ≥98% (TLC)
• form: solid
• storage condition: protect from light
• color: orange
• solubility: DMSO: 5 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Cl.CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26
• InChI: 1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H
• InChI key: HSPRASOZRZDELU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.

Features and Benefits

This compound is featured on the GRKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Photosensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)