P4743

Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Bcl-2 Binding Component 3, Anti-p53 Upregulated Modulator of Apoptosis
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD04040565
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ARR, WB
• Citations: 13

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~23 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): microarray: suitable, western blot: 2-4 μg/mL
• UniProt accession no.: Q96PG8
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BBC3(27113)

Description

General description

p53 upregulated modulator of apoptosis (PUMA) protein is a member of the B-cell lymphoma 2 (BCL2) family. It is a pro-apoptotic BCL-2 homology 3 (BH3)-only protein and has a small BH3 domain. The PUMA gene is mapped on the human chromosome at 19q13.32.

Immunogen

synthetic peptide corresponding to amino acids 2 to 16 of human PUMA-α.

Application

Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit has been used in western blotting[1] and immunoprecipitation.

Biochem/physiol Actions

p53 upregulated modulator of apoptosis (PUMA) acts as a determinant of the levels of germ cells during ovarian development. It promotes apoptosis in various cellular stress insults. Deletion of the PUMA gene is observed in several kinds of human cancers.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable