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P4380

Sigma-Aldrich

Protamine sulfate

powder

Synonym(s):

Salmine, Salmine from salmon

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About This Item

CAS Number:
53597-25-4
MDL number:
MFCD00132091
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Protamine sulfate salt from salmon, Grade II

biological source

fish (salmon)

Quality Level

200

type

Grade II

form

powder

color

white to off-white

solubility

6 M HCl: 25 mg/mL, clear, colorless to light yellow

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General description

Protamine sulfate (PS), a polycationic, positively charged protein is mostly made up of poly(l-arginine). It is obtained from salmon sperm protein.

Application

Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.
May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Biochem/physiol Actions

Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin. It is used for biomedical and biotechnological applications due to its biodegradablity.
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Quality

May contain insolubles as well as histones.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jacob F Warner et al.
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