P0740

N-(2-Phenylethyl)indomethacinamide

• Empirical Formula (Hill Notation): C₂₇H₂₅N₂O₃Cl
• CAS Number: 261766-32-9
• Molecular Weight: 460.95
• NACRES: NA.77
• PubChem Substance ID: 329820052
• UNSPSC Code: 12352200
• MDL number: MFCD02683391

Properties

• assay: ≥98% (TLC)
• Quality Segment: 200
• form: solid
• mp: 158-162 °C
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COc1ccc2n(c(C)c(CC(=O)NCCc3ccccc3)c2c1)C(=O)c4ccc(Cl)cc4
• InChI: 1S/C27H25ClN2O3/c1-18-23(17-26(31)29-15-14-19-6-4-3-5-7-19)24-16-22(33-2)12-13-25(24)30(18)27(32)20-8-10-21(28)11-9-20/h3-13,16H,14-15,17H2,1-2H3,(H,29,31)
• InChI key: VYDBTNADENXYSN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Inhibits human recombinant and ovine cyclooxygenase-2 (COX-2) with IC₅₀s of 0.06 μM and 0.125 μM, respectively; over 400-fold less potent as an inhibitor of COX-1.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)