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P0622

Sigma-Aldrich

PET-cGMP

≥98% (HPLC), solid

Synonym(s):

β-Phenyl-1,N2-ethenoguanosine 3′,5′-monophosphate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C18H15N5O7PNa
CAS Number:
78080-27-0
Molecular Weight:
467.30
MDL number:
MFCD04118064
UNSPSC Code:
12352200
PubChem Substance ID:
24724570
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

packaging

pkg of 10 μmol

color

white

solubility

H2O: ~10 mmol

shipped in

dry ice

storage temp.

−70°C

SMILES string

[Na+].O[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3cnc4C(=O)N5C=C(NC5=Nc34)c6ccccc6

InChI

1S/C18H16N5O7P.Na/c24-13-14-11(7-28-31(26,27)30-14)29-17(13)23-8-19-12-15(23)21-18-20-10(6-22(18)16(12)25)9-4-2-1-3-5-9;/h1-6,8,11,13-14,17,24H,7H2,(H,20,21)(H,26,27);/q;+1/p-1/t11-,13-,14-,17-;/m1./s1

InChI key

IGIOCJJIGJLGKR-TZNCIMHNSA-M

Biochem/physiol Actions

cGMP-dependent protein kinase (PKG I and PKG II) activator. Potent membrane permeant activator of both isozymes I α and I β of cGMP-dependent protein kinase. Common stimulators such as 8-Br-cGMP or 8-pCPT-cGMP mainly activate kinase subtype Iα.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
064K4730

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Potassium phosphate monobasic ACS reagent, ≥99.0%

Sigma-Aldrich

P0662

Potassium phosphate monobasic

James C Campbell et al.
ACS chemical biology, 12(9), 2388-2398 (2017-08-10)
Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP-dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due to their low isotype specificity.
Stephanie D Nofal et al.
mBio, 12(1) (2021-01-28)
Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan and ciliate
Matthew Tcheng et al.
Blood, 137(25), 3518-3532 (2021-03-16)
Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. To exploit this altered metabolism, we assessed publicly available

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