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P0184

Sigma-Aldrich

Pseudomonas exotoxin A from Pseudomonas aeruginosa

lyophilized powder

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0.5 MG
$520.20

About This Item

CAS Number:
91262-95-2
MDL number:
MFCD00132134
UNSPSC Code:
12352200
NACRES:
NA.77

$520.20

List price$578.00Save 10%
Web-Only Promotion
Check Cart for Availability
Request a Bulk Order

form

lyophilized powder

Quality Level

200

composition

Protein, ~30% E1%/280

storage temp.

2-8°C

General description

Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.[1]

Biochem/physiol Actions

Pseudomonas exotoxin A functions as an anticancer agent.[1]
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.[2]
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.

Packaging

Package size based on protein content.

Physical form

Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000100593
0000100593
059M4153V
11181148
065M4071V

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Pseudomonas exotoxin A: from virulence factor to anti-cancer agent
Wolf P and Elsasser-Beile U
International Journal of Medical Microbiology : IJMM, 299(3), 161-176 (2009)
Preparation of Pseudomonas exotoxin A.
K J Kozak et al.
Methods in enzymology, 165, 147-152 (1988-01-01)
B H Iglewski et al.
Infection and immunity, 15(1), 138-144 (1977-01-01)
Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as
Mutations in the Elongation Factor 2 Gene Which Confer Resistance to Diphtheria Toxin and Pseudomonas Exotoxin A GENETIC AND BIOCHEMICAL ANALYSES
Foley BT, et al.
The Journal of Biological Chemistry, 270(39), 23218-23225 (1995)
J L Middlebrook et al.
Canadian journal of microbiology, 23(2), 183-189 (1977-02-01)
The sensitivities of 21 mammalian cell lines to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae were measured. Each line exhibited 1-4 log differences in sensitivities to the two toxins. No species-specific sensitivities were noted for Pseudomonas exotoxin while diphtheria
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