M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
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About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
Recommended Products
biological source
mouse (CD-1)
Quality Level
form
liquid
packaging
vial of ~10 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Mgst1(56615)
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General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Application
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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