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M0398

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone

elastase inhibitor, powder, ≥98% (TLC)

Synonym(s):

N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$188.00
10 mg

Available to ship TODAYfromMILWAUKEE

$321.00
$272.85
25 mg

Available to ship TODAYfromMILWAUKEE

$606.00

About This Item

Empirical Formula (Hill Notation):
C22H35ClN4O7
CAS Number:
Molecular Weight:
502.99
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
6167019

$188.00


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Product Name

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor

Quality Segment

assay

≥98% (TLC)

form

powder

mp

159 °C

solubility

methanol: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)CCl

InChI

1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1

InChI key

PJGDFLJMBAYGGC-XLPNERPQSA-N

General description

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

Application

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone has been used as an elastase specific inhibitor.[1]

Biochem/physiol Actions

Irreversible inhibitor of human leukocyte[2] and neutrophil[3] elastase.
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).

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This Item
454454B7632M4765
assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

300

form

powder

form

solid

form

powder

form

powder

solubility

methanol: 50 mg/mL, clear, colorless

solubility

ethanol: 1 mg/mL, DMF: 5 mg/mL, DMSO: 5 mg/mL

solubility

methanol: 20 mg/mL, clear, colorless to light yellow

solubility

DMF: soluble 25 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

mp

159 °C

mp

-

mp

-

mp

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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