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L5288

Latrunculin B

from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor

Synonym(s):

LAT-B

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Size/SKUAvailabilityPrice
1 mg

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$355.00

About This Item

Empirical Formula (Hill Notation):
C20H29NSO5
CAS Number:
76343-94-7
Molecular Weight:
395.51
UNSPSC Code:
12352200
PubChem Substance ID:
329817621
NACRES:
NA.77
MDL number:
MFCD00270879
Assay:
≥80% (HPLC)
Form:
solid

$355.00

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Product Name

Latrunculin B from Latruncula magnifica, ≥80% (HPLC), solid

Quality Segment

200

assay

≥80% (HPLC)

form

solid

mol wt

395.5

solubility

ethanol: soluble

storage temp.

−20°C

SMILES string

C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChI key

NSHPHXHGRHSMIK-JRIKCGFMSA-N

General description

Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.

Application

Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.

Biochem/physiol Actions

Latrunculin B inhibits actin polymerization in vitro. Latrunculin B disrupts microfilament-mediated processes.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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This Item
428020L5163428021
Latrunculin B from Latruncula magnifica ≥80% (HPLC), solid

Sigma-Aldrich

L5288

Latrunculin B from Latruncula magnifica

Latrunculin B, Latrunculia magnifica Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

Sigma-Aldrich

428020

Latrunculin B, Latrunculia magnifica

Latrunculin A from sea sponge, ≥85% (HPLC), waxy solid

Sigma-Aldrich

L5163

Latrunculin A

Latrunculin A, Latrunculia magnifica Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

Sigma-Aldrich

428021

Latrunculin A, Latrunculia magnifica

assay

≥80% (HPLC)

assay

≥95% (HPLC)

assay

≥85% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

waxy solid

form

solid

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

mol wt

395.5

mol wt

-

mol wt

421.6

mol wt

-

solubility

ethanol: soluble

solubility

DMSO: 25 mg/mL, ethanol: 25 mg/mL, methanol: 50 mg/mL

solubility

DMSO: soluble, ethanol: soluble

solubility

DMSO: 25 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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