L3625

α-Lactose monohydrate

≥99% total lactose basis (GC)

• Synonym(s): β-D-Gal-(1→4)-α-D-Glc, 4-O-β-D-Galactopyranosyl-α-D-glucose, Milk sugar
• Empirical Formula (Hill Notation): C₁₂H₂₂O₁₁ · H₂O
• CAS Number: 5989-81-1
• Molecular Weight: 360.31
• MDL number: MFCD00150747
• UNSPSC Code: 12352201
• PubChem Substance ID: 57654326
• NACRES: NA.25

Properties

• biological source: bovine milk
• assay: ≥99% total lactose basis (GC)
• form: powder
• impurities: ≤0.05% Glucose; ≤4% β-lactose
• color: white to off-white
• mp: 219 °C ((426 °F ))
• solubility: water: 100 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: [H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
• InChI: 1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
• InChI key: WSVLPVUVIUVCRA-KPKNDVKVSA-N

Description

Application

• Crystal size, a key character of lactose crystallization affecting microstructure, surface chemistry and reconstitution of milk powder.: This study uses alpha-lactose monohydrate as a standard to investigate how crystal size affects the physical properties of milk powder, which is crucial for optimizing production processes in the dairy industry (Qi X et al., 2024).


• Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with alpha-Lactose Monohydrate.: Explores the critical role of alpha-lactose monohydrate, as an excipient together with terbutaline sulfate in optimizing particle interactions for enhanced performance of inhalable therapeutics (Ma CY et al., 2023).


• Terahertz time-domain spectroscopy for the investigation of tablets prepared from roller compacted granules.: This research utilizes alpha-lactose monohydrate to examine the properties of pharmaceutical tablets, offering insights into material characteristics that affect drug delivery systems (Anuschek M et al., 2023).

Biochem/physiol Actions

Lactose is a dissacharide formed by the condensation of one galactose and one glucose molecule. Lactose is the major sugar in the milk of most species, typically present between 2-8%.

alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)