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I9534

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

Name: Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat
Brand: SIGMA

clone 122404, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-Igf-II, Anti-Igf2, Anti-Mpr, Anti-Peg2

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

122404, monoclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: 2-8 μg/mL
western blot: 1-2 μg/mL

isotype

IgG2a

UniProt accession no.

P09535

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Igf2(16002)

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Biochem/physiol Actions

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.

Description

Pricing

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.

Robert G Maki

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(33), 4985-4995 (2010-10-27)

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the

IGF2: epigenetic regulation and role in development and disease.

Wendy Chao et al.

Cytokine & growth factor reviews, 19(2), 111-120 (2008-03-01)

Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all

Insulin-like growth factor system and sporadic malignant melanoma.

Ettore Capoluongo

The American journal of pathology, 178(1), 26-31 (2011-01-13)

Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications.

C J Rosen

Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)

The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated

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