H8291
Platelet-Derived Growth Factor-AA human
PDGF-AA, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Synonym(s):
PDGF−AA
About This Item
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biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤2000 ng/mL Specific activity ED50
quality
endotoxin tested
mol wt
dimer 35-45 kDa (glycosylated)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PDGFA(5154)
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General description
The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3.[5][6] PDGF is structurally and functionally related to vascular endothelial growth factors.[6]
Application
Biochem/physiol Actions
The sources of PDGF during wound repair include platelets (predominantly PDGF-AB), smooth muscles (PDGF-A),18 monocyte-derived macrophages (PDGF-B),19 and endothelial cells (PDGF- B).20 PDGF may play a role during normal embryonic development.
Purified PDGF activates two distinct PDGF receptors encoded by separate genes. PDGF-AA binds only to -PDGF receptor but PDGF-AB and PDGF-BB bind to both alpha and β-receptors; i.e., the alpha-receptor binds either A or B chain and the β-receptor binds only the B chain.
Preparation Note
Analysis Note
Legal Information
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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