F7057
Folate Receptor 2 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonym(s):
FOLR2, Folate Receptor beta
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.56
Recommended Products
biological source
human
Quality Level
recombinant
expressed in CHO cells
assay
≥95% (SDS-PAGE)
form
lyophilized
impurities
≤1.0 EU/μg endotoxin
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Gene Information
human ... FOLR2(2350)
application
Folate Receptor 2 has been used in studies of the treatment of rheumatoid arthritis (RA) with Methotrexate (MTX). These studies have focused on transport of MTX through folate receptor 2 in RA synovial macrophages.
Biochem/physiol Actions
Folate Receptor 2 is a 38kDa protein that has a high affinity for folic acid and mediates 5-methyltetrahydrofolate to the inside of the cell.
Physical form
Lyophilized from PBS
Reconstitution
Reconstitute at 100 μg/ mL in PBS
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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