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Fetuin from fetal bovine serum

Name: Fetuin from fetal bovine serum
Brand: SIGMA

lyophilized powder, suitable for cell culture

Synonym(s):

Fetuin from fetal calf serum

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About This Item

CAS Number:

9014-81-7

UNSPSC Code:

12352202

EC Number:

232-762-7

NACRES:

NA.61

MDL number:

MFCD00131055

Form:

lyophilized powder

Biological source:

bovine serum (fetal)

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biological source

bovine serum (fetal)

Quality Level

200

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H₂O: 1 mg/mL, colorless to faint yellow or tan

UniProt accession no.

Q58D62

storage temp.

2-8°C

Gene Information

bovine ... FETUA(504615)

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Related Categories

Bovine Serum Albumin

Cell Culture & Analysis

Molecular Biology & Functional Genomics

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Show Differences

1 of 1

This Item	F3385	341506	F3004
Sigma-Aldrich F2379 Fetuin from fetal bovine serum	Sigma-Aldrich F3385 Fetuin from fetal bovine serum	Sigma-Aldrich 341506 Fetuin, Fetal Bovine Serum	Sigma-Aldrich F3004 Fetuin from fetal bovine serum
biological source bovine serum (fetal)	biological source -	biological source bovine serum	biological source bovine serum (fetal)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) HPLC: suitable, MALDI-MS: suitable
form lyophilized powder	form lyophilized powder	form lyophilized solid	form lyophilized powder
UniProt accession no. Q58D62	UniProt accession no. -	UniProt accession no. P12763, Q58D62	UniProt accession no. Q58D62
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
Gene Information bovine ... FETUA(504615)	Gene Information -	Gene Information bovine ... AHSG(280988), FETUB(504615)	Gene Information bovine ... FETUB(504615)

General description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Application

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Fetuin from fetal bovine serum has been used:

to synthesize primary and secondary calciprotein particles (CPP)
to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
as a supplement in Ham′s F10 media for myoblast culture.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete

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Global Trade Item Number

SKU	GTIN
F2379-25G	04061833629857
F2379-250MG	04061833261651
F2379-5G	04061833620229
F2379-100MG	04061833261644
F2379-1G	04061833612910

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