This material is only slightly soluble in water at a reported rate of 11.7 mg/L. The solubility of this product is tested in DMSO at a minimum rate of 20 mg/mL, with most lots soluble at 40 mg/mL. Other reported solvents include chloroform, ethanol, methanol and n-propanol. Following solubilization in any of the solvents listed above, stock solutions may typically be diluted with aqueous solvents or buffers.
F1293
Finasteride
≥98% (HPLC), Selective 5α-reductase inhibitor, powder
Synonym(s):
N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $127.00 |
About This Item
Empirical Formula (Hill Notation):
C23H36N2O2
CAS Number:
Molecular Weight:
372.54
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
$127.00
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Product Name
Finasteride, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: soluble >20 mg/mL
storage temp.
room temp
SMILES string
[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
InChI
1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChI key
DBEPLOCGEIEOCV-WSBQPABSSA-N
Gene Information
human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)
Application
Finasteride has been used:
- as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
- in culture medium to treat tumor cells in vitro
- as a positive control to treat benign prostatic hyperplasia (BPH)
- to examine its effect on structural and molecular biology on the ventral prostate of senile mice
Biochem/physiol Actions
Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.
Selective 5α-reductase inhibitor; antiandrogen.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form - | form solid | form - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: soluble >20 mg/mL | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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