F0504

Folate binding protein from bovine milk

lyophilized powder

• Synonym(s): Folate Protein
• UNSPSC Code: 12352202
• NACRES: NA.61
• MDL number: MFCD00131098
• Form: lyophilized powder
• Biological source: bovine milk

Properties

• biological source: bovine milk
• form: lyophilized powder
• usage: mg sufficient for ~4,000 assays
• composition: Protein, 20-40% modified Warburg-Christian
• technique(s): ligand binding assay: suitable, surface plasmon resonance (SPR): suitable
• capacity: 1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)
• storage temp.: −20°C

Description

Application

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.

Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.[1][2][3]

Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.

Biochem/physiol Actions

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing buffer salt as sodium citrate

Analysis Note

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)