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E7159

Sigma-Aldrich

Exo2

≥98% (HPLC)

Synonym(s):

2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

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5 MG
$89.68
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$264.00

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5 MG
$89.68
25 MG
$264.00

About This Item

Empirical Formula (Hill Notation):
C18H18N4O2S
CAS Number:
304684-77-3
Molecular Weight:
354.43
MDL number:
MFCD00380179
UNSPSC Code:
12352200
PubChem Substance ID:
329799006
NACRES:
NA.77

$89.68

List price$94.40
Web-Only Promotion

Available to ship onApril 08, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23

InChI

1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+

InChI key

VFNUTEMVQGLDAG-ZVBGSRNCSA-N

Biochem/physiol Actions

Exo2 acts as a chemical probe of intracellular transport.
Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.
Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN).[1] It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000199646
0000153004
0000153004
069K4618V
0000199646

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Yan Feng et al.
EMBO reports, 5(6), 596-601 (2004-05-22)
Cholera toxin (CT) follows a glycolipid-dependent entry pathway from the plasma membrane through the trans-Golgi network (TGN) to the endoplasmic reticulum (ER) where it is retro-translocated into the cytosol to induce toxicity. Whether access to the Golgi apparatus is necessary
Lexiang Ji et al.
The Plant cell, 31(10), 2315-2331 (2019-08-24)
Somatic embryogenesis is an important tissue culture technique that sometimes leads to phenotypic variation via genetic and/or epigenetic changes. To understand the genomic and epigenomic impacts of somatic embryogenesis, we characterized soybean (Glycine max) epigenomes sampled from embryos at 10
Liwei Lang et al.
Journal of experimental & clinical cancer research : CR, 36(1), 112-112 (2017-08-24)
Although major improvements have been made in surgical management, chemotherapeutic, and radiotherapeutic of prostate cancer, many prostate cancers remain refractory to treatment with standard agents. Therefore, the identification of new molecular targets in cancer progression and development of novel therapeutic
Ayaka Hieno et al.
Plant physiology, 180(3), 1629-1646 (2019-05-09)
Hydrogen peroxide (H2O2) is a common signal molecule initiating transcriptional responses to all the known biotic and abiotic stresses of land plants. However, the degree of involvement of H2O2 in these stress responses has not yet been well studied. Here
Gertrud Wiedemann et al.
The Plant cell, 30(3), 717-736 (2018-03-09)
RecQ DNA helicases are genome surveillance proteins found in all kingdoms of life. They are characterized best in humans, as mutations in RecQ genes lead to developmental abnormalities and diseases. To better understand RecQ functions in plants we concentrated on
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