E0514

E-64c

Calpain Inhibitor

• Synonym(s): (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane
• Empirical Formula (Hill Notation): C₁₅H₂₆N₂O₅
• CAS Number: 76684-89-4
• Molecular Weight: 314.38
• UNSPSC Code: 12352202
• PubChem Substance ID: 24894369
• MDL number: MFCD00132882

Properties

• biological source: synthetic (organic)
• assay: ≥98% (HPLC)
• form: powder
• solubility: ethanol: 20 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O
• InChI: 1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
• InChI key: SCMSYZJDIQPSDI-SRVKXCTJSA-N
• Gene Information: human ... CAPN1(823)

Description

Biochem/physiol Actions

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor.

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Other Notes

Synthetic analog of E-64

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)