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D5314

DPQ

≥98% (HPLC), solid

Synonym(s):

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$122.00
5 mg

Available to ship TODAYfromMILWAUKEE

$415.00
$352.75

About This Item

Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
Molecular Weight:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$122.00


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biological source

synthetic (organic)

Quality Segment

assay

≥98% (HPLC)

form

solid

mp

107-109  °C

solubility

DMSO: 1 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

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This Item
300270O1016SML1349
description

≥98% (HPLC), solid

description

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

≥98% (HPLC)

description

≥98% (HPLC)

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 1 mg/mL, clear, colorless to faintly yellow

solubility

DMSO: 5 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

mp

107-109  °C

mp

-

mp

-

mp

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves



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