D3321

Dipeptidyl Peptidase VII human

recombinant, expressed in Sf9 cells

• Synonym(s): DPP7, Quiescent cell proline dipeptidase
• UNSPSC Code: 12352204
• NACRES: NA.54
• EC Number: 3.4.14.-
• Specific activity: ≥1,500 units/μg protein, ≥1500 units/μg protein
• Recombinant: expressed in Sf9 cells

Properties

• recombinant: expressed in Sf9 cells
• Quality Segment: 200
• form: solution
• specific activity: ≥1,500 units/μg protein, ≥1500 units/μg protein
• mol wt: 89.1 kDa
• relevant disease(s): diabetes; cardiovascular diseases
• shipped in: dry ice
• storage temp.: −70°C

Description

General description

Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa

Application

Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes [1]. DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research [2].

Biochem/physiol Actions

DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Physical form

Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.

Other Notes

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

Safety Information

• pictograms: GHS08,GHS05
• signalword: Danger
• hcodes: H314,H360D
• pcodes: P202 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2