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D0761

Sigma-Aldrich

Diacetoxyscirpenol

from Fusarium sambucinum

Synonym(s):

12,13-Epoxytrichothec-9-ene-3,4,15-triol-4,15-diacetate, 4β,15-Diacetoxy-3α-hydroxy-12,13 epoxy-trichothec-9-ene, Anguidin

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About This Item

Empirical Formula (Hill Notation):
C19H26O7
CAS Number:
2270-40-8
Molecular Weight:
366.41
Beilstein/REAXYS Number:
1354986
EC Number:
218-873-3
MDL number:
MFCD00866334
UNSPSC Code:
12352200
PubChem Substance ID:
24893292

biological source

Fusarium sambucinum

storage temp.

2-8°C

SMILES string

CC(=O)OC[C@]12CCC(C)=C[C@H]1O[C@@H]3[C@H](O)[C@@H](OC(C)=O)[C@@]2(C)[C@@]34CO4

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Do Youn Jun et al.
Toxicology and applied pharmacology, 222(2), 190-201 (2007-06-15)
To understand the mechanism underlying T-cell toxicity of diacetoxyscirpenol (DAS) from Fusarium sambucinum, its apoptogenic as well as growth retardation activity was investigated in human Jurkat T cells. Exposure to DAS (0.01-0.15 microM) caused apoptotic DNA fragmentation along with caspase-8
J Brake et al.
Poultry science, 78(12), 1690-1694 (2000-01-08)
Two experiments were conducted to determine the effects of 4,15-diacetoxyscirpenol (DAS) on fertility and hatchability of broiler breeders. In Experiment 1, naturally mated broiler breeders were studied. A limited daily allocation of feed containing 0 (basal), 1.25, 2.5, or 5.0
J Brake et al.
Poultry science, 79(6), 856-863 (2000-06-30)
Three experiments were conducted to determine the effects of 4,15-diacetoxyscirpenol (DAS) on BW, feed consumption, and oral lesions of broiler breeders. In Experiment 1, caged broiler breeder hens were fed 0, 5, 10, or 20 mg DAS/kg diet from 24
L F Kubena et al.
Poultry science, 76(2), 256-264 (1997-02-01)
The individual and combined effects of feeding diets containing 300 mg fumonisin B1 (FB1), and 4 mg diacetoxyscirpenol (DAS) or 3 mg ochratoxin A (OA) were evaluated in two experiments using female turkey poults (Nicholas Large Whites) from day of
R Froquet et al.
Human & experimental toxicology, 20(2), 84-89 (2001-05-01)
Trichothecenes are mycotoxins produced by various species of fungi, which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and the most potent trichothecenes. Consumption of
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