D0754

3,5-Diiodo-L-tyrosine dihydrate

Name: 3,5-Diiodo-<SC>L</SC>-tyrosine dihydrate
Brand: SIGMA
Price: 108 USD
Availability: InStock

≥98.0% (HPLC), suitable for ligand binding assays

Synonym(s):

3,5-diiodo-L-tyrosine hydrate (1:2)

Slide 1 of 1

Select a Size

10 G

$108.00

Available to ship TODAYDetails

Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):

C₉H₉I₂NO₃ · 2H₂O

CAS Number:

18835-59-1

Molecular Weight:

469.01

NACRES:

NA.26

PubChem Substance ID:

24893289

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

206-092-0

MDL number:

MFCD00016542

Beilstein/REAXYS Number:

2218691

Key Documents

View All Documentation

Product Name

3,5-Diiodo-L-tyrosine dihydrate, crystalline

assay

≥98.0% (HPLC)

Quality Level

200

form

crystalline

technique(s)

ligand binding assay: suitable

color

white

mp

200 °C (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear, yellow-green

storage temp.

−20°C

SMILES string

N[C@@H](Cc1cc(I)c(O)c(I)c1)C(O)=O

InChI

1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1

InChI key

NYPYHUZRZVSYKL-ZETCQYMHSA-N

Related Categories

Amino Acids – Building Blocks of Life Science

Biochemicals

Cell Culture Supplements & Reagents

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	D0629	93829	F4505
Sigma-Aldrich D0754 3,5-Diiodo-L-tyrosine dihydrate	Sigma-Aldrich D0629 3,5-Diiodo-L-thyronine	Sigma-Aldrich 93829 L-Tyrosine	Sigma-Aldrich F4505 m-Fluoro-DL-tyrosine
form crystalline	form powder	form powder or crystals	form powder
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
assay ≥98.0% (HPLC)	assay ≥99% (HPLC)	assay ≥99.0% (NT)	assay ≥98%
storage temp. −20°C	storage temp. −20°C	storage temp. -	storage temp. 2-8°C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
mp 200 °C (dec.) (lit.)	mp 255 °C	mp >300 °C (dec.) (lit.)	mp 280 °C (dec.) (lit.)

Application

Substrate for the assay of halogenated tyrosine and thyroid hormone aminotransferase.[1] Intermediate in the biosynthesis and alternative pathways of metabolism of thyroid hormones.[2]

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose.

Jana Frýdlová et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 135-140 (2008-02-08)

The interaction of porcine pepsin A with immobilized derivatives of aromatic amino acids was investigated. Divinyl sulfone-activated Sepharose was used to immobilize N-acetyl-l-phenylalanine and 3,5-diiodo-l-tyrosine via their free carboxyl groups and l-tyrosine via its amino group. Immobilized l-tyrosine was iodinated

Chiral discrimination of D- and L-amino acids using iodinated tyrosines as chiral references: effect of iodine substituent.

Sangeeta Kumari et al.

Journal of the American Society for Mass Spectrometry, 18(8), 1516-1524 (2007-06-26)

L-Tyrosine and iodinated L-tyrosines, i.e., 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine, are successfully used as chiral references for the chiral discrimination of aliphatic, acidic, and aromatic amino acids. Chiral discrimination is achieved by investigating the collision-induced dissociation spectra of the trimeric complex [Cu(II)(ref)(2)(A)

Identification and quantitation of iodotyrosines and iodothyronines in hydrolysate of iodinated casein by capillary electrophoresis.

Yining Zheng et al.

Talanta, 69(1), 107-112 (2008-10-31)

In this paper, a new method for separation, identification and quantitation of iodotyrosines and iodothyronines [3-monoiodo-L-tyrosine (MIT), 3,5-diiodo-L-tyrosine (DIT), L-thyronine (T(0)), 3,5-diiodo-L-thyronine (T(2)), 3,5,3'-triiodo-L-thyronine (T(3)) and 3,3',5,5'-tetraiodo-L-thyronine (T(4))] was described by using capillary electrophoresis with photodiode-array ultraviolet-visible detection (CE-UV). The

Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria.

M Nakano

The Journal of biological chemistry, 242(1), 73-81 (1967-01-10)

Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.

A Balsam et al.

The Journal of clinical investigation, 72(4), 1234-1245 (1983-10-01)

Studies were performed to elucidate the nature of the pathway of hepatic thyroxine (T4) metabolism that is activated by inhibitors of liver catalase. For this purpose, the metabolism of T4 in homogenates of rat liver was monitored with T4 labeled

View All Related Papers

Global Trade Item Number

SKU	GTIN
D0754-10G	04061833558041

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service